The Mesolimbic Dopamine System From Motivation To Action

The Mesolimbic Dopamine System From Motivation To Action

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the mesolimbic pathway sometimes referred to as the reward pathway is a dopaminergic pathway in the brain the pathway connects the ventral tegmental area in the midbrain to the ventral striatum of the basal ganglia in the forebrain the ventral striatum includes the nucleus accumbens and the olfactory tubercle the release of dopamine from the mesolimbic pathway into the nucleus accumbens brain reward pathways the most important reward pathway in brain is the mesolimbic dopamine system this circuit vta nac is a key detector of a rewarding stimulus initiation of addictive behaviour dopamine is released in the mesolimbic dopamine system of the brain to signal reward and pleasure if a behaviour causes dopamine release then the brain knows to do it again e g eating drinking keeping warm having sex these are adaptive behaviours in evolutionary terms as they help an organism species to survive in its environment dopamine da a contraction of 3 4 dihydroxyphenethylamine is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body it is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical l dopa which is synthesized in the brain and kidneys dopamine is also synthesized in plants and most animals levels of dopamine in the brain especially the prefrontal cortex help in improved working memory however this is a delicate balance and as levels increase or decrease to abnormal levels